Therapeutic Potential of Bioactive Flavonoids from Citrus Fruit Peels toward Obesity and Diabetes Mellitus

Obesity is associated with a significantly increased risk of cardiovascular and metabolic diseases such as diabetes mellitus. Recently, growing body evidence shows that phytochemicals, especially many flavonoids, place an inhibitory regulatory effect on adipogenesis, obesity diabetes. With computer-aided drug discovery, the action modes more bioactive flavonoids are being identified confirmed at molecular level. Citrus fruit peels particularly rich in which have demonstrated strong therapeutic potentials regulating lipid metabolisms. However, they usually thrown away after consuming flesh, sometimes even causing environmental problems. Thus, extraction useful from citrus waste for pharmaceutical industry could be profitable environmentally friendly solution future, advocating concepts circular economy sustainable society. The aim this review to summarize current antiobesity antidiabetic extracted fruits. Our results suggest various potential sources novel drugs nutraceuticals. Combining experimental data artificial intelligence methods study would facilitate discovery against obesity-related diseases.